According to research published in the Journal of Neuroscience, caffeine intake not only appears to protect against Alzheimer's but may actually help those who already have the disease.

Researchers at the Byrd Alzheimer's Institute in Florida have reported that five cups of coffee a day could protect humans in the same way that the caffeine equivalent appears to have in the study of mice.

In a controlled study experiment using Alzheimer's mice, one group of mice had caffeine added to their drinking water. The memory of mice who drank the caffeinated water was roughly similar to mice to had no Alzheimer's. Researchers also found that levels of beta-amyloid proteins reduced in mice who drank caffeine. Beta-amyloid proteins aggregate into plaques within the brain and are present in the brains of people with Alzheimer's disease.

Some interesting results were also obtained when researchers gave caffeine to aged Alzheimer's mice who already had high levels of beta-amyloid protein in their brains. It was discovered that caffeine reduced the levels of beta-amyloid already present in the brain. This could suggest that coffee drinking is beneficial in people with Alzheimer's; for the time being this is speculation.

The therapeutic effects of caffeine over the long-term have been noted in relation to reduced risk of type 2 diabetes, Parkinson's disease, cirrhosis of the liver, cancer of the liver, colorectal cancer and suicide. Although caffeine has been suspected of causing high blood pressure the association appears stronger when caffeine is consumed via soft drinks.

Coffee may reduce your risk factors for Alzheimer's disease.

Article Source: G. W. Arendash, et al., Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain beta-amyloid production, Neuroscience (2006), doi: 10.1016/j.neuroscience.2006.07.021

More Information About the Johnnie B.Byrd Alzheimer’s Institute in Tampa, Florida,

Boston University School of Medicine (BUSM) researchers have found that pictures allow patients with very mild Alzheimer’s disease (AD) to better recognize and identify a subject as compared to using just words. In addition, the researchers found that these patients can rely on a general sense of knowing or familiarity but not recollection to support successful recognition. These findings appear in the current issue of the journal Neuropsychologia.

Mild cognitive impairment (MCI) has been conceptualized as a transitional stage between healthy aging and Alzheimer’s disease (AD). The amnestic subtype of MCI has received a great deal of attention as it has been associated with an estimated tenfold increase in Alzheimer’s disease compared to age-matched controls with no cognitive impairment.
Patients with amnestic MCI and controls participated in separate recognition memory tests of words and pictures, while high density event-related potentials (ERPs) were recorded during memory retrieval. These ERPs allow researchers to understand the underlying brain activity associated with certain cognitive processes. The results of the study showed that frontally based ERP components typically associated with memorial familiarity and post-retrieval monitoring were similar between both groups for retrieval of pictures. However, these components were diminished in the patient group during the retrieval of words.

“The results suggested that patients with very mild Alzheimer’s, or amnestic mild cognitive impairment, were able to rely on intact frontally-based cognitive processes, such as implicit conceptual priming and explicit memorial familiarity, to remember pictures,” said study author Brandon Ally, PhD, an assistant professor of neurology at BUSM.

According to the researchers, this is a novel finding with regards to how people conceptualize memory retrieval, particularly in patients with dementia. “Perhaps there is more of an interaction of implicit and explicit memory processes than we once thought, and patients with mild AD can successfully use implicit memory, or memory without conscious awareness, to support recognition. If this is the case, perhaps we can develop strategies that rely on implicit memory processes such as conceptual priming to support new learning in patients with AD, allowing them to live more engaged and independent lives,” added Ally. “Overall, the current results have shown that pictures and words differentially affect how memorial decisions are made in patients with aMCI. Pictures have a clear memorial advantage over words, but the debate as to why is far from settled.”

Future research by Ally and his team will attempt to translate these findings into real-world interventions to help patients with memory problems.

Funding for this study was provided by grants from the National Institute on Aging and by pilot awards from the Boston University Alzheimer’s Disease Center, the Harvard NeuroDiscovery Center and the Bedford VA Hospital in Bedford, Mass.